What's the science behind anger management? Anger is a normal and healthy emotion – it motivates us to address injustice. While it's healthy to be angry and passionate about an issue, it's also important to be able to regulate this anger and control aggressive impulses that arise as a result. Serotonin is one neurotransmitter that can help us with that process. Genetic research on serotonin explores how genes affect serotonin and aggression.
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Jetzt kostenlos anmeldenWhat's the science behind anger management? Anger is a normal and healthy emotion – it motivates us to address injustice. While it's healthy to be angry and passionate about an issue, it's also important to be able to regulate this anger and control aggressive impulses that arise as a result. Serotonin is one neurotransmitter that can help us with that process. Genetic research on serotonin explores how genes affect serotonin and aggression.
Finally, we will evaluate the serotonin explanation of aggression.
Fig. 1 - Research suggests that serotonin can calm us dow, regulate mood and improve self-control.
To understand how serotonin can help regulate aggression, we need first to understand the neurobiology of aggression.
The brain structure associated with generating aggressive impulses is called the limbic system.
The limbic system is a complex structure which is involved in emotional responses, it consists of a few other structures, some of which are the hippocampus, the amygdala, and the hypothalamus.
When we are under threat, the amygdala can produce intense feelings of anger, which often drive aggressive behaviours. The orbitofrontal cortex can regulate these impulses from the limbic system, a structure associated with executive function and emotional regulation.
The orbitofrontal cortex processes information from other brain structures, including the limbic system, and engages in decision-making regarding this information and inhibits aggressive impulses.
Serotonin is considered to be a key neurotransmitter in the communication between the limbic system and the orbitofrontal cortex. It can stabilise our mood, calm our anger and promote self-control.
Serotonin is a neurotransmitter linked with regulating mood, attention, behaviour and physiological processes like sleep, digestion, or temperature.
The serotonin explanation of aggression proposes that low levels of this neurotransmitter can impair self-control over impulses, resulting in an inability to regulate one's anger.
It's possible that a genetic predisposition to lower serotonin levels could affect people's self-control over aggressive impulses in response to perceived provocation or threat. We therefore need to look into serotonin turnover rates.
Two genes that influence serotonin levels have been linked to aggression– genes associated with the tryptophan hydroxylase enzyme and the MAOA gene; these genes affect serotonin production and metabolism.
Passamonti et al. (2012) conducted a study investigating the effects of lower serotonin levels on aggression. The researchers manipulated the levels of serotonin in participants' brains by changing participants' diets.
The findings demonstrated that the activity of the frontal lobe as well as the connection between the limbic system and the frontal lobe were reduced in participants with lower serotonin in response to angry faces only. These findings suggest that lower serotonin levels can impair one's control of aggressive impulses, as marked by lower frontal lobe activity.
The study conducted by Passamonti et al. (2012) was a double-blind, placebo-controlled trial, meaning that the 30 participants recruited were assigned to either a diet low in tryptophan or a normal diet (placebo). Neither participants nor researchers knew what participant was in which condition to ensure objectivity in measurements.
Fig. 2 - To investigate how the prefrontal cortex activity is affected by depleted serotonin Passamonti et al. (2012) conducted fMRI scans on their participants.
Another piece of evidence for the association between lower serotonin levels and aggression comes from the George et al. (2001) study.
Even though lower levels of serotonin have been associated with less control over impulsive aggression, a rare genetic mutation, which causes higher levels of serotonin, has also been associated with greater levels of aggression.
Short-variant of the MAOA gene has been associated with impaired serotonin breakdown and, therefore, higher serotonin levels. Individuals with this variant of the MAOA gene have been found to display more aggressive and violent behaviour.
The MAOA gene affects the Monoamine oxidase A enzyme (MAO-A), which breaks down several neurochemicals, including serotonin and dopamine.
Brunner et al. (1993) assessed male members of a Dutch family in which borderline mental retardation and complex behavioural problems were common and found a genetic mutation in the structure of the MAOA gene.
The study concluded that the participants' behavioural issues were likely related to the abnormal variation of the MAOA gene.
Brunner and colleagues' study was quasi-experimental; they couldn't manipulate the participants' genes, as it would be unethical. However, another study, which manipulated the MAOA genes in mice, has confirmed Brunner's findings.
Cases et al. (1995) manipulated the gene that codes for MAOA in mice and caused the gene to be deleted that encodes for MAOA, which causes a deficiency of the MAO-A enzyme.
Both fearfulness and aggression are linked to the activity of the amygdala. Excessive fearfulness and aggression could be caused by the inability to regulate this activity due to an impaired connection between the orbitofrontal cortex and the limbic system.
This study suggests that the inability to regulate serotonin levels causes behavioural issues in mice.
Dopamine can also be implicated in the control of aggression. Lower levels of serotonin have also been found to elevate dopamine levels, which have also been associated with aggression in animals (Seo et al., 2008).
Fig. 2 - Individuals with this variant of the MAOA gene have been found to display more aggressive and violent behaviour.
Changes in serotonin levels have been linked to aggression by a variety of studies, including both correlational and experimental studies, which gives the serotonin explanation credibility. The evidence comes from both animal studies and studies conducted on humans.
However, it is unclear why both elevated and lower levels of serotonin increase aggressive tendencies.
This explanation of aggression can be considered reductionist, it ignores the potential social, cultural and environmental influences on aggression or how they interact with our biology. However, this reductionist model has allowed researchers to make testable hypotheses and collect experimental evidence.
This theory also supports the notion of biological determinism. Abnormal levels of serotonin in the brain or genetic abnormalities are proposed to make people incapable of controlling their behaviour. This position is problematic, as it puts into question people's free will and the ethics of legal punishment of behaviours that people potentially can't control.
The transporter gene is responsible for transporting serotonin out of the synaptic cleft. This allows more serotonin to be released into the cleft and stops the action of serotonin when needed. If anything interferes with this process, it can cause problems with regulation of mood and emotions, including happiness. However, an excess of serotonin in the cleft eventually leads to desensitisation to serotonin and a lower level of happiness.
Several activities release serotonin: going out in the sun, experiencing or thinking about happy things, or conversely, being threatened or experiencing a fearful situation.
Genes affect serotonin in multiple ways, through the synthesis of serotonin (lowering or increasing production), serotonin transportation, and the uptake of serotonin after it has been produced.
Yes. If the genetic components for serotonin production/synthesis are affected, it will cause issues that could result in low serotonin levels.
There’s not a single gene that completely controls serotonin. However, genes such as the TPH gene and the MAOA gene affect the synthesis and degradation of serotonin.
What is serotonin?
A neurotransmitter.
What brain structure is involved in regulating emotional responses?
The orbitofrontal cortex.
What is the function of the limbic system?
The limbic system is a complex system which is involved in emotional responses,.
When does the amygdala respond with feelings of anger?
When we are faced with a potential threat.
What is the function of the orbitofrontal cortex?
The orbitofrontal cortex processes the information received from other brain structures including the limbic system, engages in decision-making in relation to this information, and inhibits aggressive impulses.
What is the role of serotonin in relation to aggression?
Serotonin is considered to be a key neurotransmitter in the communication between the limbic system and the orbitofrontal cortex. It can stabilise our mood, calm the anger and promote self-control.
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